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Explore Molecular Prior Knowledge

OmniPath integrates data from 150+ resources to provide a comprehensive view of molecular interactions, pathways, and biological annotations.

Explore InteractionsBrowse Annotations
Interactions Browser
Explore undirected, directed and causal molecular interactions

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Filter by interaction type, direction, and more

Reference Tracking

Access original publications and sources

Data Export

Download results in multiple formats

Browse Interactions
Annotations Browser
Discover functional annotations, localizations, and biological properties

Functional Annotations

GO terms, pathways, and functions, and more

Localization Data

Cellular and subcellular locations

Intercellular Roles

Ligands, receptors, and signaling

Browse Annotations
Experimental
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Database Resources Overview
Comprehensive listing of all 168 resources with 14,683,328 total records
Showing 168 of 168 resources
MSigDB
Annotations
CC BY 4.0Creative Commons Attribution 4.0 International
Frequent Updates5,895,462
HPA
AnnotationsIntercellular
CC BY-SA 3.0Creative Commons Attribution-ShareAlike 3.0 International
Frequent Updates2,058,879
UniProt
InteractionsAnnotationsIntercellular
CC BY 4.0Creative Commons Attribution 4.0 International
Frequent Updates801,478
DoRothEA
Interactions
CompositeConstituting databases carry their own licenses
No Updates750,939
PAZAR
Interactions
LGPLv3GNU Lesser General Public License version 3
No Updates424,791
ReMap
Interactions
CC BY 4.0Creative Commons Attribution 4.0 International
Infrequent Updates321,452
Vesiclepedia
Annotations
CC BY 4.0Creative Commons Attribution 4.0 International
Infrequent Updates295,464
PROGENy
Annotations
Apache 2.0Apache License, version 2.0
No Updates233,277
CytoSig
Annotations
CytoSigCytoSig License
Infrequent Updates200,408
ComPPI
AnnotationsIntercellular
CC BY-SA 4.0Creative Commons Attribution-ShareAlike 4.0 International
No Updates183,381
SIGNOR
InteractionsAnnotationsEnzyme-SubstrateComplexes
CC BY 4.0Creative Commons Attribution 4.0 International
Frequent Updates180,364
PhosphoSite
InteractionsEnzyme-Substrate
CC BY-NC-SA 3.0Creative Commons Attribution-NonCommercial-ShareAlike 3.0 International
Frequent Updates155,378
Ramilowski
AnnotationsIntercellular
CC BY 4.0Creative Commons Attribution 4.0 International
No Updates153,362
HPRD
InteractionsEnzyme-Substrate
HPRDHPRD License
No Updates153,200
Wang
InteractionsAnnotations
CC BY-NC 3.0Creative Commons Attribution-NonCommercial 3.0 International
No Updates145,773
CollecTRI
Interactions
CompositeConstituting databases carry their own licenses
Infrequent Updates144,380
DisGeNet
Annotations
CC BY-NC-SA 4.0Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International
Frequent Updates129,190
OmniPath
Intercellular
CC BY 4.0Creative Commons Attribution 4.0 International
Frequent Updates120,129
ProtMapper
InteractionsEnzyme-Substrate
CC BY 4.0Creative Commons Attribution 4.0 International
Infrequent Updates114,540
SPIKE
InteractionsComplexes
CC BY 4.0Creative Commons Attribution 4.0 International
No Updates107,119
ExTRI
Interactions
CC BY 4.0Creative Commons Attribution 4.0 International
No Updates105,276
InterPro
Annotations
CC0 1.0Creative Commons Zero 1.0 Universal
Frequent Updates98,741
TRRUST
Interactions
CC BY-SA 4.0Creative Commons Attribution-ShareAlike 4.0 International
Infrequent Updates73,899
HINT
Interactions
Unspecified NC-SAUnspecified Non-commercial Redistributable
Infrequent Updates70,205
GO
AnnotationsIntercellular
CommercialFrequent Updates65,267
ENCODE-proximal
Interactions
CC BY 4.0Creative Commons Attribution 4.0 International
Infrequent Updates63,316
HTRIdb
Interactions
LGPLv3GNU Lesser General Public License version 3
No Updates54,470
Phobius
AnnotationsIntercellular
CC BY 4.0Creative Commons Attribution 4.0 International
No Updates51,741
ENCODE-distal
Interactions
CC BY 4.0Creative Commons Attribution 4.0 International
Infrequent Updates49,646
phosphoELM
InteractionsEnzyme-Substrate
ELMELM Software License Agreement
No Updates48,466
MIMP
InteractionsEnzyme-Substrate
LGPLv3GNU Lesser General Public License version 3
Infrequent Updates47,995
KEA
InteractionsEnzyme-Substrate
Unspecified NC-SAUnspecified Non-commercial Redistributable
No Updates46,959
IntAct
Interactions
CC BY 4.0Creative Commons Attribution 4.0 International
Frequent Updates46,614
LOCATE
AnnotationsIntercellular
NAR Open AccessNucleic Acids Research Open Access
No Updates45,051
REACH
InteractionsEnzyme-Substrate
CC BY 4.0Creative Commons Attribution 4.0 International
Infrequent Updates42,950
KEGG
InteractionsAnnotations
KEGGKEGG License
Frequent Updates41,927
DGIdb
AnnotationsIntercellular
MITMIT License
Frequent Updates40,556
HGNC
AnnotationsIntercellular
HGNCHGNC License
Frequent Updates39,452
Exocarta
Annotations
CC BY 4.0Creative Commons Attribution 4.0 International
Infrequent Updates36,098
NTNU.Curated
Interactions
CC BY 4.0Creative Commons Attribution 4.0 International
No Updates32,219
Lit-BM-17
Interactions
CC BY 4.0Creative Commons Attribution 4.0 International
No Updates30,491
Sparser
InteractionsEnzyme-Substrate
CC BY 4.0Creative Commons Attribution 4.0 International
Infrequent Updates30,371
ARACNe-GTEx
Interactions
CC BY 4.0Creative Commons Attribution 4.0 International
No Updates30,065
CSPA
AnnotationsIntercellular
CC BY 4.0Creative Commons Attribution 4.0 International
No Updates25,717
PhosphoPoint
Interactions
CC BY-SA 4.0Creative Commons Attribution-ShareAlike 4.0 International
No Updates25,682
HOCOMOCO
Interactions
CC BY 4.0Creative Commons Attribution 4.0 International
Frequent Updates25,676
GEREDB
Interactions
AFL 3.0Academic Free License v3.0
No Updates24,811
TopDB
AnnotationsIntercellular
CC BY-NC 4.0Creative Commons Attribution-NonCommercial 4.0 International
Frequent Updates23,085
JASPAR
Interactions
CC BY 4.0Creative Commons Attribution 4.0 International
Frequent Updates22,679
Cellinker
InteractionsAnnotationsComplexesIntercellular
CC BY-NC 4.0Creative Commons Attribution-NonCommercial 4.0 International
Infrequent Updates21,921
HuRI
Interactions
CC BY 4.0Creative Commons Attribution 4.0 International
Infrequent Updates21,832
iPTMnet
Interactions
CC BY-NC-SA 4.0Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International
Frequent Updates21,800
NetPath
InteractionsAnnotations
CC BY 2.5Creative Commons Attribution 2.5 International
No Updates19,487
RegNetwork
Interactions
LGPLv3GNU Lesser General Public License version 3
Infrequent Updates18,473
TRED
Interactions
NAR Open AccessNucleic Acids Research Open Access
No Updates18,473
CellTalkDB
InteractionsAnnotationsIntercellular
GPLv3GNU General Public License version 3
Infrequent Updates18,366
HumanCellMap
Annotations
CC BY 4.0Creative Commons Attribution 4.0 International
No Updates17,481
HPMR
InteractionsAnnotationsIntercellular
CC BY-NC 4.0Creative Commons Attribution-NonCommercial 4.0 International
No Updates17,428
InnateDB
Interactions
DSLDesign Science License
Infrequent Updates16,856
LRdb
InteractionsAnnotationsIntercellular
GPLv3GNU General Public License version 3
Infrequent Updates16,238
TFactS
Interactions
CommercialNo Updates15,955
hu.MAP3
Complexes
CC BY 4.0Creative Commons Attribution 4.0 International
Unknown15,433
CORUM
AnnotationsComplexes
CC BY-NC 4.0Creative Commons Attribution-NonCommercial 4.0 International
Frequent Updates15,226
Almen2009
AnnotationsIntercellular
CC BY 4.0Creative Commons Attribution 4.0 International
No Updates15,099
BioGRID
Interactions
MITMIT License
Frequent Updates14,755
connectomeDB2020
InteractionsAnnotationsIntercellular
MITMIT License
Infrequent Updates14,567
PhosphoNetworks
InteractionsEnzyme-Substrate
PhosphoNetworksPhosphoNetworks License
No Updates14,272
hprd
InteractionsEnzyme-Substrate
Academic/Non-profitNo Updates14,078
Surfaceome
AnnotationsIntercellular
CC BY 4.0Creative Commons Attribution 4.0 International
No Updates13,888
CellPhoneDB
InteractionsAnnotationsComplexesIntercellular
MITMIT License
Infrequent Updates13,678
Ramilowski2015
InteractionsAnnotationsIntercellular
CC BY 4.0Creative Commons Attribution 4.0 International
No Updates13,322
scConnect
InteractionsAnnotationsIntercellular
MITMIT License
Infrequent Updates13,289
Cui2007
Interactions
CC BY 4.0Creative Commons Attribution 4.0 International
No Updates13,229
iTALK
InteractionsAnnotationsIntercellular
CC BY-NC-SA 3.0Creative Commons Attribution-NonCommercial-ShareAlike 3.0 International
Infrequent Updates13,167
CellChatDB
InteractionsAnnotationsComplexesIntercellular
GPLv3GNU General Public License version 3
Frequent Updates13,154
talklr
InteractionsAnnotationsIntercellular
GPLv3GNU General Public License version 3
No Updates11,325
RLIMS-P
InteractionsEnzyme-Substrate
CC BY 4.0Creative Commons Attribution 4.0 International
No Updates11,231
ICELLNET
InteractionsAnnotationsComplexesIntercellular
GPLv3GNU General Public License version 3
Frequent Updates11,014
NetworKIN
Interactions
CC BY 4.0Creative Commons Attribution 4.0 International
No Updates10,720
Compleat
Complexes
CC BY-SA 4.0Creative Commons Attribution-ShareAlike 4.0 International
Infrequent Updates9,695
CellCellInteractions
AnnotationsIntercellular
CellCellInteractionsCellCellInteractions License
Infrequent Updates9,366
Baccin2019
InteractionsAnnotationsIntercellular
CC BY-NC 4.0Creative Commons Attribution-NonCommercial 4.0 International
No Updates9,298
PDB
Complexes
PDBPDB License
Frequent Updates9,235
ACSN
Interactions
CC BY 4.0Creative Commons Attribution 4.0 International
Infrequent Updates9,065
MatrixDB
AnnotationsIntercellular
CC BY 4.0Creative Commons Attribution 4.0 International
Frequent Updates8,748
miRTarBase
Interactions
miRTarBasemiRTarBase License
Frequent Updates8,425
PanglaoDB
Annotations
InformalInformal license
No Updates8,211
HTRI
Interactions
LGPLv3GNU Lesser General Public License version 3
No Updates8,008
DoRothEA-A
Interactions
InformalInformal license
No Updates7,640
Fantom5
Interactions
CC BY 4.0Creative Commons Attribution 4.0 International
No Updates7,429
NCI-PID
InteractionsEnzyme-Substrate
BSD3-clause BSD License
No Updates7,405
hu.MAP2
Complexes
CC BY 4.0Creative Commons Attribution 4.0 International
Infrequent Updates7,044
DIP
Interactions
CC BY-ND 3.0Creative Commons Attribution-NoDerivatives 3.0 International
No Updates7,031
Guide2Pharma
InteractionsAnnotationsComplexesIntercellular
CC BY-SA 3.0Creative Commons Attribution-ShareAlike 3.0 International
Frequent Updates6,966
Reactome
InteractionsEnzyme-Substrate
CC0 1.0Creative Commons Zero 1.0 Universal
Frequent Updates6,927
Matrisome
AnnotationsIntercellular
CC BY-NC 4.0Creative Commons Attribution-NonCommercial 4.0 International
Infrequent Updates6,771
KEGG-MEDICUS
InteractionsComplexes
CC BY-SA 4.0Creative Commons Attribution-ShareAlike 4.0 International
Frequent Updates6,531
EMBRACE
InteractionsAnnotationsIntercellular
CC BY 4.0Creative Commons Attribution 4.0 International
No Updates6,348
DOMINO
Interactions
CC BY 2.5Creative Commons Attribution 2.5 International
No Updates6,119
dbPTM
InteractionsEnzyme-Substrate
NAR Open AccessNucleic Acids Research Open Access
Infrequent Updates5,942
Membranome
AnnotationsIntercellular
Apache 2.0Apache License, version 2.0
Infrequent Updates5,713
Adhesome
InteractionsAnnotationsIntercellular
CC BY 4.0Creative Commons Attribution 4.0 International
Infrequent Updates5,547
NetworkBlast
Complexes
CC BY 4.0Creative Commons Attribution 4.0 International
No Updates5,535
HPRD-phos
Interactions
HPRDHPRD License
No Updates5,505
SignaLink3
Interactions
CC BY-SA 3.0Creative Commons Attribution-ShareAlike 3.0 International
Infrequent Updates5,150
SignaLink
AnnotationsIntercellular
CC BY-SA 3.0Creative Commons Attribution-ShareAlike 3.0 International
Infrequent Updates5,125
CancerDrugsDB
InteractionsAnnotations
Unspecified NC-SAUnspecified Non-commercial Redistributable
Frequent Updates5,045
CytReg
Interactions
CC BY 4.0Creative Commons Attribution 4.0 International
Infrequent Updates4,899
hu.MAP
Complexes
CommercialInfrequent Updates4,545
CellCall
InteractionsAnnotationsIntercellular
Artistic-2.0Artistic License 2.0
Infrequent Updates4,492
GPCRdb
AnnotationsIntercellular
CC BY 4.0Creative Commons Attribution 4.0 International
Frequent Updates4,485
BEL-Large-Corpus
InteractionsEnzyme-Substrate
NAR Open AccessNucleic Acids Research Open Access
Infrequent Updates4,287
STRING
Interactions
CC BY 4.0Creative Commons Attribution 4.0 International
Frequent Updates4,172
Pavlidis2021
Interactions
CC BY 4.0Creative Commons Attribution 4.0 International
No Updates4,134
TransmiR
Interactions
CC BY-NC 4.0Creative Commons Attribution-NonCommercial 4.0 International
Infrequent Updates3,788
DEPOD
InteractionsEnzyme-Substrate
CC BY-NC 4.0Creative Commons Attribution-NonCommercial 4.0 International
Infrequent Updates3,642
Macrophage
Interactions
CC BY 4.0Creative Commons Attribution 4.0 International
No Updates3,476
Lambert2018
Annotations
EULElsevier User License
No Updates3,424
TCDB
Annotations
CC BY-SA 3.0Creative Commons Attribution-ShareAlike 3.0 International
Frequent Updates3,296
CancerCellMap
Interactions
CC BY 2.5Creative Commons Attribution 2.5 International
No Updates3,268
CA1
Interactions
CC BY 4.0Creative Commons Attribution 4.0 International
No Updates3,130
KEGG-PC
Annotations
PathwayCommonsPathwayCommons License
Frequent Updates2,927
ncRDeathDB
Interactions
CC BY-NC 4.0Creative Commons Attribution-NonCommercial 4.0 International
No Updates2,905
CancerSEA
Annotations
CC BY-NC 4.0Creative Commons Attribution-NonCommercial 4.0 International
Infrequent Updates2,760
Kinexus
Interactions
CC BY 4.0Creative Commons Attribution 4.0 International
No Updates2,719
ELM
Interactions
ELMELM Software License Agreement
Frequent Updates2,609
TFcensus
Annotations
CC BY 4.0Creative Commons Attribution 4.0 International
No Updates2,430
GOA
Interactions
CC BY 4.0Creative Commons Attribution 4.0 International
Frequent Updates2,417
CPAD
Annotations
No licenseNo license
No Updates2,350
LMPID
Interactions
CC BY-NC 2.0Creative Commons Attribution-NonCommercial 2.0 International
No Updates2,223
ComplexPortal
Complexes
CC BY 4.0Creative Commons Attribution 4.0 International
Frequent Updates2,210
DLRP
Interactions
Unspecified NC-SAUnspecified Non-commercial Redistributable
Infrequent Updates2,151
ORegAnno
Interactions
LGPLv3GNU Lesser General Public License version 3
No Updates2,110
Zhong2015
AnnotationsIntercellular
CC BY 4.0Creative Commons Attribution 4.0 International
No Updates2,060
Li2012
InteractionsEnzyme-Substrate
CC BY-NC 3.0Creative Commons Attribution-NonCommercial 3.0 International
No Updates2,049
CellChatDB-cofactors
Interactions
GPLv3GNU General Public License version 3
Frequent Updates1,787
TFe
Interactions
CC BY-SA 3.0Creative Commons Attribution-ShareAlike 3.0 International
No Updates1,577
Kirouac2010
InteractionsAnnotationsIntercellular
CC BY-NC-ND 3.0Creative Commons Attribution-NonCommercial-NoDerivs 3.0 International
No Updates1,289
Wojtowicz2020
Interactions
CC BY 4.0Creative Commons Attribution 4.0 International
No Updates1,182
miRecords
Interactions
miRecordsmiRecords License
No Updates1,120
FANTOM4
Interactions
CommercialNo Updates1,083
ENCODE
Interactions
CC BY 4.0Creative Commons Attribution 4.0 International
Infrequent Updates1,031
MPPI
Interactions
MPPIMPPI License
No Updates1,020
kinase.com
Annotations
Kinase.comKinase.com License
No Updates920
CellTypist
Annotations
CC BY 3.0Creative Commons Attribution 3.0 International
Frequent Updates880
IntOGen
Annotations
CC0 1.0Creative Commons Zero 1.0 Universal
Frequent Updates835
CancerGeneCensus
Annotations
COSMICCOSMIC License
Frequent Updates763
DoRothEA-reviews
Interactions
CC BY 4.0Creative Commons Attribution 4.0 International
No Updates738
CFinder
Complexes
CC BY 4.0Creative Commons Attribution 4.0 International
Infrequent Updates713
TCRcuration
Interactions
CC BY-SA 3.0Creative Commons Attribution-ShareAlike 3.0 International
Infrequent Updates661
TRRD
Interactions
CC BY 4.0Creative Commons Attribution 4.0 International
No Updates637
Havugimana2012
Complexes
CommercialNo Updates622
TRIP
Interactions
CC BY-NC-SA 3.0Creative Commons Attribution-NonCommercial-ShareAlike 3.0 International
No Updates454
miR2Disease
Interactions
Academic/Non-profitNo Updates360
miRDeathDB
Interactions
Academic/Non-profitNo Updates331
NRF2ome
Interactions
CC BY-SA 3.0Creative Commons Attribution-ShareAlike 3.0 International
No Updates318
MCAM
AnnotationsIntercellular
Unspecified NC-SAUnspecified Non-commercial Redistributable
No Updates299
ARN
Interactions
CC BY-SA 3.0Creative Commons Attribution-ShareAlike 3.0 International
Infrequent Updates295
Phosphatome
Annotations
CommercialNo Updates264
PDZBase
Interactions
Unspecified NC-SAUnspecified Non-commercial Redistributable
No Updates254
Integrins
AnnotationsIntercellular
CC BY 4.0Creative Commons Attribution 4.0 International
No Updates203
AlzPathway
Interactions
CC BY 3.0Creative Commons Attribution 3.0 International
Infrequent Updates193
OPM
AnnotationsIntercellular
Apache 2.0Apache License, version 2.0
Infrequent Updates181
DeathDomain
Interactions
NAR Open AccessNucleic Acids Research Open Access
Frequent Updates118
NFIRegulomeDB
Interactions
LGPLv3GNU Lesser General Public License version 3
No Updates107
lncrnadb
Interactions
NAR Open AccessNucleic Acids Research Open Access
No Updates58
LncRNADisease
Interactions
Academic/Non-profitInfrequent Updates54
cellsignal.com
Interactions
No licenseNo license
Infrequent Updates51
By Category
Interactions:115
Annotations:67
Enzyme-Substrate:18
Complexes:18
Intercellular:42
By License
Academic/Non-profit:43
Commercial:121
No License:2
Composite:2
By Maintenance
Frequent:40
Infrequent:49
No Updates:78

About OmniPath

OmniPath is a database of molecular biology prior knowledge, combining data from over 150 resources to build 5 integrated databases:

  • Signaling network (interactions)
  • Enzyme-PTM relationships
  • Protein complexes
  • Protein annotations (function, localization, tissue, disease, structure)
  • Intercellular communication roles (ligand, receptor, intercell)

OmniPath Statistics

150+
Data Resources
5
Integrated Databases
1M+
Interactions
5M+
Annotations